Wayfli › Airports › Cayo Largo del Sur (CYO)

Direct flights from Cayo Largo del Sur Vilo Acuña International Airport (CYO)

Cayo Largo del Sur Vilo Acuña International Airport in Cayo Largo del Sur, Cuba has direct flights to 2 airports in 1 country, flown by 1 airline. The longest is to Santiago De Cuba (SCU) at 621 km.

See every route from CYO on the map

2direct destinations

1countries

1airlines

Direct flights from CYO by country

Cuba (2)

HAV Havana · 177 km · ~45m · Cubana
SCU Santiago De Cuba · 621 km · ~1h 15m · Cubana

Airlines flying from CYO

Cubana

Going somewhere CYO doesn’t fly direct?

Wayfli finds the best one- and two-stop connections from Cayo Largo del Sur to any airport in the world. Pick a destination on the map.

Routes come from current airline fares, updated weekly (last update 9 November 2026), plus older schedule data for airports with few recent fares. “Direct” can include a few same-plane flights with a stop. Flight times are estimates from distance. Always check with the airline before booking.